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RxGen has broad expertise in a range of technologies and capabilities to advance drug discovery and development. These capabilities in combination with access to African green monkey models represent a strong competitive advantage for preclinical validation of novel therapeutics.
Pharmacokinetics and Drug Delivery
Understanding the delivery, distribution and disposition of a compound is a key element to any drug development project. RxGen has experience in the pharmacokinetic analysis of small molecules and biologics through multiple routes of delivery, including intravenous, oral and ocular. The African green monkey is as predictive as cynomolgus and rhesus and superior to rat or dog, ensuring investigators more accurate information with rapid turnaround to guide the development process.
Gene Therapy
RxGen scientist have an established record of accomplishment in the exploration and validation of new technologies for the in vivo up and down regulation of genes and microRNAs in nonhuman primates, with expertise in viral vector delivery, gene silencing and other methodologies administered through multiple routes, including intracranial, intramuscular and intravenous.
Predictive Models of Human Diseases and Disorders
RxGen has experience with models of many human conditions based on over 25 years of primate research and over 800 scientific publications by members of the team. Expertise in pharmacology, physiology, surgery, stereotactic techniques, and reproductive biology allow extensive modeling capabilities.
RxGen routinely employs the following models to assess drug efficacy and validate therapeutic targets:
- Parkinson’s disease
- Memory and cognition
- Metabolic disorders
- Ophthalmic conditions
- Surgical models
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